Destabilization of the Organized Structure of Ventricular Fibrillation During Reperfusion

Aim: to study the effect of reperfusion on organized frequency-amplitude structure ventricular fibrillation (VF) in dog heart. Materials and methods. We conducted 4 experiments 8 dogs. In each experiment, isolated heart one was perfused with blood second (supporting) dog. an artificially heart, 6 episodes 3-minute ischemia 10-minute were performed VF (1-2 ischemia-reperfusion experiment). Each episode preceded by a perfusion VF. Ventricular electrogram recorded during episodes. A (spectral) analysis one-second segments performed, proportion (in %) 0.5-15 Hz frequency oscillations 10-second determined perfusion, (M±m, n=60). The structures compared stable taken as control. nonparametric Welch criterion “The R Project for Statistical Computing” software environment used compare parameters reperfusion. Results. 9-10 dominated first 30 seconds ischemia, amplitude dominant did not significantly change vs control obtained cardiac perfusion. decrease up 6.5-7.5 Hz, - 26% documented at 3rd minute ischemia. At 1st reperfusion, increased 13.5-14.5 but remained reduced 26%, 2nd decreased 9.5-10.5 33%. stabilized 3-10 minutes reperfusion: accounted 32-33% spectral power. Conclusion. Reperfusion is characterized transient destabilization procedure. regains stabilization within 2-10 Cardiac intentionally induced can be instead cardioplegia major surgery boost resistance prevent or reduce complications.